The Center for Osteoporosis and Metabolic Bone Diseases

Publications

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Fu Q, Manolagas SC, O’Brien CA. Parathyroid Hormone Controls Receptor Activator of NFκB Ligand Gene Expression via Distant Transcriptional Enhancer. Molecular and Cellular Biology, 26(17):6453-6468, 2006. [PM:16914731]*

Plotkin LI, Manolagas SC, Bellido T. Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs. Bone, 39(3):443-452, 2006 [PM:16627025]*

Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, Bellido TM. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone and Miner Res, 21(4):605-615, 2006. [PM: 16598381]*

Manolagas SC. Perspective: Choreography from the tomb: an emerging role of dying osteocytes in the purposeful, and perhaps not so purposeful, targeting of bone remodeling. BoneKEy-Osteovision. 2006 January; 3(1):5-14, 2006. [bonekey-ibms.org]

Almeida M, Han L, O’Brien CA, Kousteni S, Manolagas SC. Classical Genotropic versus Nongenotropic (Kinase-Initiated) Regulation of Gene Transcription by the Estrogen Receptor. Endocrinology, 147(4):1986-96, 2006. [PM: 16384865]*

Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S. Wnts prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta -catenin-dependent as well as independent signaling cascades involving Src/ERK and PI3K/Akt. J Biol Chem, 280(50):41342-51, 2005. [PM: 16251184]*

Parsons CA, Mroczkowski HJ, McGuigan FEA, Albagha OME, Manolagas S, Reid DM, Ralston SH, Shmookler Reis RJ. Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22. Human Molecular Genetics; 14(21):3141-8, 2005. [PM: 16183656]*

Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'brien CA, Manolagas SC, Jilka RL. Chronic Elevation of PTH in Mice Reduces Expression of Sclerostin by Osteocytes: a Novel Mechanism for Hormonal Control of Osteoblastogenesis. Endocrinology, 146(11):4577-83, 2005. [PM: 16081646]*

O’Brien CA, Jilka RL, Fu Q, Stewart S, Weinstein RS, and Manolagas SC. IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice. AJP: Endocrinology and Metabolism; 289(5):E784-93, 2005. [PM: 15956054]*

Plotkin LI, Mathov I, Aguirre JI, Parfitt AM, Manolagas SC, Bellido T. Mechanical stimulation prevents osteocyte apoptosis through an integrin/src/erk signalsome localized in caveolae. American Journal of Physiology (Cell Physiology).   Am J Physiol Cell Physiol, 289:C633-C643; 2005. [PM: 15872009]*

Ali AA, Weinstein RS, Stewart SA, Parfitt AM, Manolagas SC, Jilka RL. Rosiglitazone Causes Bone Loss in Mice by Suppressing Osteoblast Differentiation and Bone Formation. Endocrinology 146(3):1226-1235. 2005. [PM:15591153]

Chen JR, Plotkin LI, Aguirre JI, Han L, Jilka RL, Kousteni S, Bellido T, Manolagas SC. Transient Versus Sustained Phosphorylation and Nuclear Accumulation of ERKs Underlie Anti-Versus Pro-Apoptotic Effects of Estrogens. J Biol Chem 280(6):4632-4638. 2005. [PM:15557324]

Plotkin LI, Aguirre JI, Kousteni S, Manolagas SC, Bellido T. Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis Via Distinct Molecular Mechanisms Downstream of Extracellular Signal-Regulated Kinase Activation. J Biol Chem 280(8):7317-7325. 2005. [PM:15590626]

Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC. Nongenotropic, Anti-Apoptotic Signaling of 1alpha,25(OH)2-Vitamin D3 and Analogs Through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes. Mediation by Src, Phosphatidylinositol 3-, and JNK Kinases. J Biol Chem 280(14):14130-14137. 2005. [PM:15671029]

Weinstein RS, Manolagas SC. Apoptosis in Glucocorticoid-Induced Bone Disease. Current Opinion in Endocrinology and Diabetes. 12:219-223. 2005.

Manolagas SC, Kousteni S, Chen JR, Schuller M, Plotkin L, Bellido T. Kinase-Mediated Transcription, Activators of Nongenotropic Estrogen-Like Signaling (ANGELS), and Osteoporosis: a Different Perspective on the HRT Dilemma. Kidney Int Suppl (91):S41-S49. 2004. [PM:15461702]

O'Brien CA, Jia D, Plotkin LI, Bellido T, Powers CC, Stewart SA, Manolagas SC, Weinstein RS. Glucocorticoids Act Directly on Osteoblasts and Osteocytes to Induce Their Apoptosis and Reduce Bone Formation and Strength. Endocrinology 145(4):1835-1841. 2004. [PM:14691012]

Weinstein RS, Jia D, Powers CC, Stewart SA, Jilka RL, Parfitt AM, Manolagas SC. The Skeletal Effects of Glucocorticoid Excess Override Those of Orchidectomy in Mice. Endocrinology 145(4):1980-1987. 2004. [PM:14715712]

Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-Induced Anti-Apoptotic Signaling in Osteoblasts. A Putative Explanation for Why Intermittent Administration Is Needed for Bone Anabolism. J Biol Chem 278(50):50259-50272. 2003. [PM:14523023]

Jilka, R. L., Shmookler Reis, R. J., Manolagas, S. C. Age-related bone loss: lessons from the osteoporotic SAMP6 mouse model. In The Senescence Accelerated Mouse (SAM): An Animal Model of Senescence. Eds: Nomura, Y., Takeda, T., and Okuma, Y. New York:Elsevier. 2003.

Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T, Manolagas SC. Kinase-Mediated Regulation of Common Transcription Factors Accounts for the Bone-Protective Effects of Sex Steroids. J Clin Invest 111(11):1651-1664. 2003. [PM:12782668]

Fu Q, Jilka RL, Manolagas SC, O'Brien CA. Parathyroid Hormone Stimulates Receptor Activator of NFkappa B Ligand and Inhibits Osteoprotegerin Expression Via Protein Kinase A Activation of CAMP-Response Element-Binding Protein. J Biol Chem 277(50):48868-48875. 2002. [PM:12364326]

Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O'Brien CA, Plotkin L, Fu Q, Mancino AT, Wen Y, Vertino AM, Powers CC, Stewart SA, Ebert R, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Reversal of Bone Loss in Mice by Nongenotropic Signaling of Sex Steroids. Science 298(5594):843-846. 2002. [PM:12399595]

Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent Effects of Selective Peroxisome Proliferator-Activated Receptor-Gamma 2 Ligands on Adipocyte Versus Osteoblast Differentiation. Endocrinology 143(6):2376-2384. 2002. [PM:12021203]

Manolagas SC , Kousteni S, Jilka RL. Sex Steroids and Bone. Recent Prog Horm Res 57:385-409. 2002. [PM:12017554]

Manolagas SC. Estrogen Loss, Cytokines, Macrophages, Lymphocytes, Osteoclasts and Bone Loss: Six Characters in Search of an Author or an Endocrine-Immune System Relay Causing Osteoporosis? BoneKEy-Osteovision, News & Reviews, Commentaries Archive, Manolagas, Pp 2002012. 2002. [http://www.bonekey-ibms.org/cgi/content/full/ibmske;2002012]

O'Brien CA, Kern B, Gubrij I, Karsenty G, Manolagas SC. Cbfa1 Does Not Regulate RANKL Gene Activity in Stromal/Osteoblastic Cells. Bone 30(3):453-462. 2002. [PM:11882458]

Plotkin LI, Manolagas SC, Bellido T. Transduction of Cell Survival Signals by Connexin-43 Hemichannels. J Biol Chem 277(10):8648-8657. 2002. [PM:11741942]

Weinstein RS, Chen JR, Powers CC, Stewart SA, Landes RD, Bellido T, Jilka RL, Parfitt AM, Manolagas SC. Promotion of Osteoclast Survival and Antagonism of Bisphosphonate-Induced Osteoclast Apoptosis by Glucocorticoids. J Clin Invest 109(8):1041-1048. 2002. [PM:11956241]

Boyce, B. F., Xing, L., Jilka, R. L., Bellido, T., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C. Apoptosis in bone cells. In Principles of Bone Biology. Eds: Blezikian, J. P., Raisz, L. G., and Rodan, G. A. San Diego:Academic Press. 2001.

Di Gregorio GB, Yamamoto M, Ali AA, Abe E, Roberson P, Manolagas SC, Jilka RL. Attenuation of the Self-Renewal of Transit-Amplifying Osteoblast Progenitors in the Murine Bone Marrow by 17 Beta-Estradiol. J Clin Invest 107(7):803-812. 2001. [PM:11285299]

Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC. Nongenotropic, Sex-Nonspecific Signaling Through the Estrogen or Androgen Receptors: Dissociation From Transcriptional Activity. Cell 104(5):719-730. 2001. [PM:11257226]

Manolagas SC , Kousteni S. Perspective: Nonreproductive Sites of Action of Reproductive Hormones. Endocrinology 142(6):2200-2204. 2001. [PM:11356663]

Manolagas SC. Manipulating Programmed Cell Death for Better Living! Sci STKE 2001(87):E1-2001. [PM:11865191]

Manolagas SC. The Role of Apoptosis in the Pathogenesis and Treatment of Osteoporosis. Medscape Diabetes & Endocrinology2001. [ http://www.medscape.com/viewarticle/413132]

Abe E, Yamamoto M, Taguchi Y, Lecka-Czernik B, O'Brien CA, Economides AN, Stahl N, Jilka RL, Manolagas SC. Essential Requirement of BMPs-2/4 for Both Osteoblast and Osteoclast Formation in Murine Bone Marrow Cultures From Adult Mice: Antagonism by Noggin. J Bone Miner Res 15(4):663-673. 2000. [PM:10780858]

Bellido T, Huening M, Raval-Pandya M, Manolagas SC, Christakos S. Calbindin-D28k Is Expressed in Osteoblastic Cells and Suppresses Their Apoptosis by Inhibiting Caspase-3 Activity. J Biol Chem 275(34):26328-26332. 2000. [PM:10835428]

Benes H, Weinstein RS, Zheng W, Thaden JJ, Jilka RL, Manolagas SC, Shmookler Reis RJ. Chromosomal Mapping of Osteopenia-Associated Quantitative Trait Loci Using Closely Related Mouse Strains. J Bone Miner Res 15(4):626-633. 2000. [PM:10780854]

Manolagas SC. Corticosteroids and Fractures: a Close Encounter of the Third Cell Kind. J Bone Miner Res 15(6):1001-1005. 2000. [PM:10841168]

Manolagas SC. Commentary on "Restoration of Bone Mass in the Severely Osteopenic Senescent Rat" Learning How to Keep Homo Sapiens Standing Tall in Old Age. J Gerontol A Biol Sci Med Sci 55(2):B81-B82. 2000. [http://biomed.gerontologyjournals.org]

Manolagas SC. Sex Steroids in Bone Remodeling. Medscape Diabetes & Endocrinology. 2000. [ http://www.medscape.com/viewarticle/419242?src=search]

Manolagas SC. Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis. Endocr Rev 21(2):115-137. 2000. [PM:10782361]

O'Brien CA, Lin SC, Bellido T, Manolagas SC. Expression Levels of Gp130 in Bone Marrow Stromal Cells Determine the Magnitude of Osteoclastogenic Signals Generated by IL-6-Type Cytokines. J Cell Biochem 79(4):532-541. 2000. [PM:10996844]

Riggs BL, Baron R, Boyle WJ, Drezner M, Manolagas SC, Martin TJ, Stewart AF, Suda T, Yasuda H, Aubin J, Goltzman D. Proposed Standard Nomenclature for New Tumor Necrosis Factor Family Members Involved in the Regulation of Bone Resorption. The American Society for Bone and Mineral Research President's Committee on Nomenclature. J Bone Miner Res 15(12):2293-2296. 2000. [PM:11127193]

Weinstein RS, Manolagas SC. Apoptosis and Osteoporosis. Am J Med 108(2):153-164. 2000. [PM:11126309]

Weinstein RS, Nicholas RW, Manolagas SC. Apoptosis of Osteocytes in Glucocorticoid-Induced Osteonecrosis of the Hip. J Clin Endocrinol Metab 85(8):2907-2912. 2000 . [PM:10946902]

Abe E, Mocharla H, Yamate T, Taguchi Y, Manolagas SC. Meltrin-Alpha, a Fusion Protein Involved in Multinucleated Giant Cell and Osteoclast Formation. Calcif Tissue Int 64(6):508-515. 1999. [PM:10341023]

Jilka RL, Weinstein RS, Bellido T, Roberson P, Parfitt AM, Manolagas SC. Increased Bone Formation by Prevention of Osteoblast Apoptosis With Parathyroid Hormone. J Clin Invest 104(4):439-446. 1999. [PM:10449436]

Lecka-Czernik B, Gubrij I, Moerman EJ, Kajkenova O, Lipschitz DA, Manolagas SC, Jilka RL. Inhibition of Osf2/Cbfa1 Expression and Terminal Osteoblast Differentiation by PPARgamma2. J Cell Biochem 74(3):357-371. 1999. [PM:10412038]

Manolagas SC , Weinstein RS. New Developments in the Pathogenesis and Treatment of Steroid-Induced Osteoporosis. J Bone Miner Res 14(7):1061-1066. 1999. [PM:10404005]

Manolagas SC. Cell Number Versus Cell Vigor--What Really Matters to a Regenerating Skeleton? Endocrinology 140(10):4377-4381. 1999. [PM:10499488]

O'Brien CA, Gubrij I, Lin SC, Saylors RL, Manolagas SC. STAT3 Activation in Stromal/Osteoblastic Cells Is Required for Induction of the Receptor Activator of NF-KappaB Ligand and Stimulation of Osteoclastogenesis by Gp130-Utilizing Cytokines or Interleukin-1 but Not 1,25-Dihydroxyvitamin D3 or Parathyroid Hormone. J Biol Chem 274(27):19301-19308. 1999. [PM:10383440]

Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T. Prevention of Osteocyte and Osteoblast Apoptosis by Bisphosphonates and Calcitonin. J Clin Invest 104(10):1363-1374. 1999. [PM:10562298]

Bellido T, O'Brien CA, Roberson PK, Manolagas SC. Transcriptional Activation of the P21(WAF1,CIP1,SDI1) Gene by Interleukin-6 Type Cytokines. A Prerequisite for Their Pro-Differentiating and Anti-Apoptotic Effects on Human Osteoblastic Cells. J Biol Chem 273(33):21137-21144. 1998. [PM:9694869]

Jilka RL, Takahashi K, Munshi M, Williams DC, Roberson PK, Manolagas SC. Loss of Estrogen Upregulates Osteoblastogenesis in the Murine Bone Marrow. Evidence for Autonomy From Factors Released During Bone Resorption. J Clin Invest 101(9):1942-1950. 1998. [PM:9576759]

Jilka RL, Weinstein RS, Bellido T, Parfitt AM, Manolagas SC. Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines. J Bone Miner Res 13(5):793-802. 1998. [PM:9610743]

Manolagas SC. Cellular and Molecular Mechanisms of Osteoporosis. Aging (Milano) 10(3):182-190. 1998. [PM:9801728]

Manolagas SC , Weinstein RS, Jilka RL, Parfitt AM. Parathyroid Hormone and Corticosteroid-Induced Osteoporosis. Lancet 352(9144):1940. 1998. [PM:9863825]

Manolagas SC. The Role of IL-6 Type Cytokines and Their Receptors in Bone. Ann N Y Acad Sci 840:194-204. 1998. [PM:9629251]

Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. The Pathophysiologic Roles of Interleukin-6 in Human Disease. Ann Intern Med 128(2):127-137. 1998. [PM:9441573]

Taguchi Y, Yamamoto M, Yamate T, Lin SC, Mocharla H, DeTogni P, Nakayama N, Boyce BF, Abe E, Manolagas SC. Interleukin-6-Type Cytokines Stimulate Mesenchymal Progenitor Differentiation Toward the Osteoblastic Lineage. Proc Assoc Am Physicians 110(6):559-574. 1998. [PM:9824538]

Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of Osteoblastogenesis and Promotion of Apoptosis of Osteoblasts and Osteocytes by Glucocorticoids. Potential Mechanisms of Their Deleterious Effects on Bone. J Clin Invest 102(2):274-282. 1998. [PM:9664068]

Bataille R, Manolagas SC, Berenson JR. Pathogenesis and Management of Bone Lesions in Multiple Myeloma. Hematol Oncol Clin North Am 11(2):349-361. 1997. [PM:9137974]

Bellido T, Borba VZ, Roberson P, Manolagas SC. Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes Osteoblast Differentiation. Endocrinology 138(9):3666-3676. 1997. [PM:9275051]

Kajkenova O, Lecka-Czernik B, Gubrij I, Hauser SP, Takahashi K, Parfitt AM, Jilka RL, Manolagas SC, Lipschitz DA. Increased Adipogenesis and Myelopoiesis in the Bone Marrow of SAMP6, a Murine Model of Defective Osteoblastogenesis and Low Turnover Osteopenia. J Bone Miner Res 12(11):1772-1779. 1997. [PM:9383681]

Lin SC, Yamate T, Taguchi Y, Borba VZ, Girasole G, O'Brien CA, Bellido T, Abe E, Manolagas SC. Regulation of the Gp80 and Gp130 Subunits of the IL-6 Receptor by Sex Steroids in the Murine Bone Marrow. J Clin Invest 100(8):1980-1990. 1997. [PM:9329961]

Mocharla H, Butch AW, Pappas AA, Flick JT, Weinstein RS, De Togni P, Jilka RL, Roberson PK, Parfitt AM, Manolagas SC. Quantification of Vitamin D Receptor MRNA by Competitive Polymerase Chain Reaction in PBMC: Lack of Correspondence With Common Allelic Variants. J Bone Miner Res 12(5):726-733. 1997. [PM:9144338]

O'Brien CA, Manolagas SC. Isolation and Characterization of the Human Gp130 Promoter. Regulation by STATS. J Biol Chem 272(23):15003-15010. 1997. [PM:9169475]

Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated Via Cells of the Osteoblastic Lineage. Endocrinology 138(9):4013-4021. 1997. [PM:9275093]

Yamate T, Mocharla H, Taguchi Y, Igietseme JU, Manolagas SC, Abe E. Osteopontin Expression by Osteoclast and Osteoblast Progenitors in the Murine Bone Marrow: Demonstration of Its Requirement for Osteoclastogenesis and Its Increase After Ovariectomy. Endocrinology 138(7):3047-3055. 1997. [PM:9202251]

Bellido T, Stahl N, Farruggella TJ, Borba V, Yancopoulos GD, Manolagas SC. Detection of Receptors for Interleukin-6, Interleukin-11, Leukemia Inhibitory Factor, Oncostatin M, and Ciliary Neurotrophic Factor in Bone Marrow Stromal/Osteoblastic Cells. J Clin Invest 97(2):431-437. 1996. [PM:8567964]