Robert S. Weinstein, M.D.

Professor of Medicine

Director, Bone Morphometry Laboratory

M.D., University of Illinois

Clinical Interests:

• Glucocorticoid-induced bone disease
• Paget's disease of bones
• Osteoporosis
• Osteomalacia
• Renal Ostedystrophy
• Fibrous dysplasia

Research Interests:

• Glucocorticoid action on bone
• Bone histomorphometry
• Densitometry and biomechanics
• Canalicular circulation

Selected Publications:

Weinstein RS, Manolagas SC. Apoptosis in Glucocorticoid-Induced Bone Disease. Current Opinion in Endocrinology and Diabetes 12:219-223. 2005.

Weinstein RS, Jia D, Powers CC, Stewart SA, Jilka RL, Parfitt AM, Manolagas SC. The Skeletal Effects of Glucocorticoid Excess Override Those of Orchidectomy in Mice. Endocrinology 145(4):1980-1987. 2004. [PM:14715712]*

O'Brien CA, Jia D, Plotkin LI, Bellido T, Powers CC, Stewart SA, Manolagas SC, Weinstein RS. Glucocorticoids Act Directly on Osteoblasts and Osteocytes to Induce Their Apoptosis and Reduce Bone Formation and Strength. Endocrinology 145(4):1835-1841. 2004. [PM:14691012]*

Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O'Brien CA, Plotkin L, Fu Q, Mancino AT, Wen Y, Vertino AM, Powers CC, Stewart SA, Ebert R, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Reversal of Bone Loss in Mice by Nongenotropic Signaling of Sex Steroids. Science 298(5594):843-846. 2002. [PM:12399595]*

Weinstein RS, Chen JR, Powers CC, Stewart SA, Landes RD, Bellido T, Jilka RL, Parfitt AM, Manolagas SC. Promotion of Osteoclast Survival and Antagonism of Bisphosphonate-Induced Osteoclast Apoptosis by Glucocorticoids. J Clin Invest 109(8):1041-1048. 2002. [PM:11956241]*

Weinstein RS. Glucocorticoid-Induced Osteoporosis. Rev Endocr Metab Disord 2(1):65-73. 2001. [PM:11708295]*

Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC. Nongenotropic, Sex-Nonspecific Signaling Through the Estrogen or Androgen Receptors: Dissociation From Transcriptional Activity. Cell 104(5):719-730. 2001. [PM:11257226]*

Abad V, Chrousos GP, Reynolds JC, Nieman LK, Hill SC, Weinstein RS, Leong GM. Glucocorticoid Excess During Adolescence Leads to a Major Persistent Deficit in Bone Mass and an Increase in Central Body Fat. J Bone Miner Res 16(10):1879-1885. 2001. [PM:11585353]*

Borton AJ, Frederick JP, Datto MB, Wang XF, Weinstein RS. The Loss of Smad3 Results in a Lower Rate of Bone Formation and Osteopenia Through Dysregulation of Osteoblast Differentiation and Apoptosis. J Bone Miner Res 16(10):1754-1764. 2001. [PM:11585338]*

Weinstein RS, Manolagas SC. Apoptosis and Osteoporosis. Am J Med 108(2):153-164. 2000. [PM:11126309]*

Weinstein RS, Nicholas RW, Manolagas SC. Apoptosis of Osteocytes in Glucocorticoid-Induced Osteonecrosis of the Hip. J Clin Endocrinol Metab 85(8):2907-2912. 2000. [PM:10946902]*

Weinstein RS. True Strength. J Bone Miner Res 15(4):621-625. 2000. [PM:10780853]*

Jilka RL, Weinstein RS, Bellido T, Roberson P, Parfitt AM, Manolagas SC. Increased Bone Formation by Prevention of Osteoblast Apoptosis With Parathyroid Hormone. J Clin Invest 104(4):439-446. 1999. [PM:10449436]*

Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T. Prevention of Osteocyte and Osteoblast Apoptosis by Bisphosphonates and Calcitonin. J Clin Invest 104(10):1363-1374. 1999. [PM:10562298]*

Additional publications listed on PubMed*

Other Information:

• Eagle Scout 1961
• Phi Beta Kappa 1966
• Alpha Omega Alpha 1970
• Medical Collge of Georgia House Staff Assoication Faculty Teaching Excellence Award 1983
• Dr. Boy Fram Memorial Award for Clinical Excellence in the Field of Bone and Mineral Metabolism presented on August 25, 1991 by the American Society for Bone and Mineral Research
• US Patent 6,660,468 B1, Dec 9, 2003: In Vitro and In Vivo Models for Screening Compounds to Prevent Glucocorticoid-induced Bone Destruction.

Dr. Weinstein's Full CV*(Adobe Acrobat Reader is required to open this file)