Stavros C. Manolagas, M.D., Ph.D.

the Thomas E. Andreoli, M.D., MACP Clinical Scholar Chair in Internal Medicine

Professor of Medicine

Director, Division of Endocrinology and Metabolism

Director, UAMS/VA Center of Osteoporosis and Metabolic Bone Diseases

Vice Chair for Research, Department of Internal Medicine

Chief, Endocrinology Section
Central Arkansas Veterans Healthcare System

M.D., University of Athens, Athens Greece

Ph.D., University of Manchester, England

Clinical Interests:

• Metabolic bone disorders
• Diseases of the parathyroid glands and other calcium disorders
• Osteoporosis
• Hormone replacement and women’s health

Research Interests:

• Vitamin D metabolism
• Interplay among hormones, cytokines, the hematopoietic/immune system and bone
• Cellular and molecular mechanisms of the pathogenesis of osteoporosis due to estrogen or androgen deficiency, old age, and glucocorticoid excess
• Mechanism of steroid hormone receptor action
• Discovery of anabolic bone therapies.

Selected Publications:

Fu Q, Manolagas SC, O’Brien CA. Parathyroid Hormone Controls Receptor Activator of NFκB Ligand Gene Expression via Distant Transcriptional Enhancer. Molecular and Cellular Biology, 26(17):6453-6468, 2006. [PM:16914731]*

Plotkin LI, Manolagas SC, Bellido T. Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs. Bone, 39(3):443-452, 2006 [PM:16627025]*

Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, Bellido TM. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone and Miner Res, 21(4):605-615, 2006. [PM: 16598381]*

Manolagas SC. Perspective: Choreography from the tomb: an emerging role of dying osteocytes in the purposeful, and perhaps not so purposeful, targeting of bone remodeling. BoneKEy-Osteovision. 2006 January; 3(1):5-14, 2006. [bonekey-ibms.org]

Almeida M, Han L, O’Brien CA, Kousteni S, Manolagas SC. Classical Genotropic versus Nongenotropic (Kinase-Initiated) Regulation of Gene Transcription by the Estrogen Receptor. Endocrinology, 147(4):1986-96, 2006. [PM: 16384865]*

Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S. Wnts prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta -catenin-dependent as well as independent signaling cascades involving Src/ERK and PI3K/Akt. J Biol Chem, 280(50):41342-51, 2005. [PM: 16251184]*

Parsons CA, Mroczkowski HJ, McGuigan FEA, Albagha OME, Manolagas S, Reid DM, Ralston SH, Shmookler Reis RJ. Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22. Human Molecular Genetics; 14(21):3141-8, 2005. [PM: 16183656]*

Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'brien CA, Manolagas SC, Jilka RL. Chronic Elevation of PTH in Mice Reduces Expression of Sclerostin by Osteocytes: a Novel Mechanism for Hormonal Control of Osteoblastogenesis. Endocrinology, 146(11):4577-83, 2005. [PM: 16081646]*

O’Brien CA, Jilka RL, Fu Q, Stewart S, Weinstein RS, and Manolagas SC. IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice. AJP: Endocrinology and Metabolism; 289(5):E784-93, 2005. [PM: 15956054]*

Plotkin LI, Mathov I, Aguirre JI, Parfitt AM, Manolagas SC, Bellido T. Mechanical stimulation prevents osteocyte apoptosis through an integrin/src/erk signalsome localized in caveolae. American Journal of Physiology (Cell Physiology).   Am J Physiol Cell Physiol, 289:C633-C643; 2005. [PM: 15872009]*

Weinstein RS, Manolagas SC. Apoptosis in glucocorticoid-induced bone disease. Current Opinion in Endocrinology and Diabetes ;12:219-223; 2005.

Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC. Nongenotropic, Anti-Apoptotic Signaling of 1alpha,25(OH)2-Vitamin D3 and Analogs Through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes. Mediation by Src, Phosphatidylinositol 3-, and JNK Kinases. J Biol Chem 280(14):14130-14137. 2005. [PM:15671029]*

Chen JR, Plotkin LI, Aguirre JI, Han L, Jilka RL, Kousteni S, Bellido T, Manolagas SC. Transient Versus Sustained Phosphorylation and Nuclear Accumulation of ERKs Underlie Anti-Versus Pro-Apoptotic Effects of Estrogens. J Biol Chem 280(6):4632-4638. 2005. [PM:15557324]*

Weinstein RS, Manolagas SC. Apoptosis in Glucocorticoid-Induced Bone Disease. Current Opinion in Endocrinology and Diabetes. 12:219-223. 2005.

O’Brien CA, Jia D, Plotkin LI, Bekkido T, Powers CC, Stewart SA, Manolagas SC, Weinstein RS. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology, 2004. 145:1835-1841. [PM:14691012]*

Weinstein RS, Jia D, Powers CC, Stewart SA, Jilka RL, Parfitt AM, Manolagas SC. The skeletal effects of glucocorticoid excess override those of orchidectomy in mice. Endocinology, 2004. 145:1980-1987. [PM:14715712]*

Ijaz MT, Manolagas SC. A patient with pseudohypoparathyroidism. J Ark Med Soc, 2003. 100:164-166.*

Bellido T, Ali AA, Plotkin L, Qiang F, Gubrij I., Roberson P, Weinstein RS, O’Brien CA, Manolagas SC, Jilka RL. Proteasomal degredation of runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts: a putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem, 2003. 278:50259-50272. [PM:14523023]*

Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T and Manolagas SC. Kinase-mediated regulation of common transcription factors accounts for the bone protective effects of sex steroids. J Clin Invest, 2003. 111:1651-1664. [PM:12782668]*

Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O’Brien CA, Plotkin L, Qiang F, Mancino AT, Wen Y, Vertino AM, Powers CC, Stewart SA, Ebert R, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Reversal of bone loss in mice by nongenotropic signaling of sex steriods. Science, 2002. 298:843-846. [PM:12399595]*

Manolagas SC and Kousteni S. Perspective: Non-reproductive sites of action of reproductive hormones. Endocrinology, 2001. 142:2200-2204. [PM:12017554]*

Di Gregorio GB, Yamamoto M, Abe E, Roberson P, Manolagas SC, Jilka RL. Attenuation of the self-renewal of transit amplifying osteoblast progenitors in the murine bone marrow by 17b-estradiol. J Clin Invest, 2001. 107:803-812. [PM:11285299]*

Kousteni S, Bellido T, Plotkin LI, O’Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC. Non-Genotropic, sex non-specific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity. Cell, 2001. 104:719-730. [PM:11257226]*

Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocrine Reviews, 2000. 21:115-137. [PM:10782361]*

Additional publications listed on PubMed*