Teresita Bellido, Ph.D.

Professor of Medicine

Ph.D., Universidad Nacional del Sur - Argentina

Postdoctoral training, Indiana University

Research Interests:

Signal transduction in bone cells. Regulation of bone cell apoptosis. Skeletal effects and mechanism of action bisphosphonates, sex steroids, parathyroid hormone and mechanical forces.

Selected Publications:

Plotkin LI, Manolagas SC, Bellido T. Dissociation of the Pro-Apoptotic Effects of Bisphosphonates on Osteoclasts From Their Anti-Apoptotic Effects on Osteoblasts/Osteocytes With Novel Analogs. Bone 39(3):443-452. 2006. [PM:16627025]*

Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, Bellido T. Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss. J Bone Miner Res 21(4):605-615. 2006. [PM:16598381]*

Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'Brien CA, Manolagas SC, Jilka RL. Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: a Novel Mechanism for Hormonal Control of Osteoblastogenesis. Endocrinology 146(11):4577-4583. 2005. [PM:16081646]*

Plotkin LI, Mathov I, Aguirre JI, Parfitt AM, Manolagas SC, Bellido T. Mechanical Stimulation Prevents Osteocyte Apoptosis: Requirement of Integrins, Src Kinases, and ERKs. Am J Physiol Cell Physiol 289(3):C633-C643. 2005. [PM:15872009]*

Plotkin LI, Aguirre JI, Kousteni S, Manolagas SC, Bellido T. Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis Via Distinct Molecular Mechanisms Downstream of Extracellular Signal-Regulated Kinase Activation. J Biol Chem 280(8):7317-7325. 2005. [PM:15590626]*

Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-Induced Anti-Apoptotic Signaling in Osteoblasts. A Putative Explanation for Why Intermittent Administration Is Needed for Bone Anabolism. J Biol Chem 278(50):50259-50272. 2003. [PM:14523023]*

Plotkin LI, Manolagas SC, Bellido T. Transduction of Cell Survival Signals by Connexin-43 Hemichannels. J Biol Chem 277(10):8648-8657. 2002. [PM:11741942]*

Kousteni S^†, Bellido T^†, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC. Nongenotropic, Sex-Nonspecific Signaling Through the Estrogen or Androgen Receptors: Dissociation From Transcriptional Activity. Cell 104(5):719-730. 2001. [PM:11257226]*
^†Both contributed equally to this work.

Mathov I, Plotkin LI, Sgarlata CL, Leoni J, Bellido T. Extracellular Signal-Regulated Kinases and Calcium Channels Are Involved in the Proliferative Effect of Bisphosphonates on Osteoblastic Cells in Vitro. J Bone Miner Res 16(11):2050-2056. 2001. [PM:11697801]*

Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T. Prevention of Osteocyte and Osteoblast Apoptosis by Bisphosphonates and Calcitonin. J Clin Invest 104(10):1363-1374. 1999. [PM:10562298]*
Featured in the cover and the comments.

Bellido T, O'Brien CA, Roberson PK, Manolagas SC. Transcriptional Activation of the P21(WAF1,CIP1,SDI1) Gene by Interleukin-6 Type Cytokines. A Prerequisite for Their Pro-Differentiating and Anti-Apoptotic Effects on Human Osteoblastic Cells. J Biol Chem 273(33):21137-21144. 1998. [PM:9694869]*

Bellido T, Borba VZ, Roberson P, Manolagas SC. Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes Osteoblast Differentiation. Endocrinology 138(9):3666-3676. 1997. [PM:9275051]*

Bellido T, Stahl N, Farruggella TJ, Borba V, Yancopoulos GD, Manolagas SC. Detection of Receptors for Interleukin-6, Interleukin-11, Leukemia Inhibitory Factor, Oncostatin M, and Ciliary Neurotrophic Factor in Bone Marrow Stromal/Osteoblastic Cells. J Clin Invest 97(2):431-437. 1996. [PM:8567964]*

Bellido T, Jilka RL, Boyce BF, Girasole G, Broxmeyer H, Dalrymple SA, Murray R, Manolagas SC. Regulation of Interleukin-6, Osteoclastogenesis, and Bone Mass by Androgens. The Role of the Androgen Receptor. J Clin Invest 95(6):2886-2895. 1995. [PM:7769130]*

Bellido T, Girasole G, Passeri G, Yu XP, Mocharla H, Jilka RL, Notides A, Manolagas SC. Demonstration of Estrogen and Vitamin D Receptors in Bone Marrow-Derived Stromal Cells: Up-Regulation of the Estrogen Receptor by 1,25-Dihydroxyvitamin-D3. Endocrinology 133(2):553-562. 1993. [PM:8393768]*

Additional publications listed on PubMed*

Dr. Bellido's Full CV* (Adobe Acrobat Reader is required to open this file)